Tacrolimus (TCRLM) loaded solid lipid nanoparticles (SLN) were prepared by solvent evaporation method and characterized for their size, polydispersity index (PDI) and entrapment efficiency (EE). The impact of various processing factors, such as homogenization speed and surfactant concentration on different quality attributes of SLN was studied for selection of best formulation. The TCRLM loaded SLN were further incorporated in gel base and investigated for drug localization in animal skin by in-vitro diffusion cell to check the feasibility for utilization of TCRLM loaded SLN in dermal localization and also compared with marketed conventional formulation for drug localization. Higher drug localization was found in SLN based gel when compared to marketed formulation. This long duration of retention of TCRLM in animal skin proved a drug localization effect through SLN.
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